Overview

Research and development (R&D) at Atrimed is an ongoing process of innovation, introduction, and improvement of its products. We conduct research with the objective of developing affordable products to alleviate auto-immune diseases, especially Acne, Psoriasis and Eczema. Our R&D function is driven by a talent pool that has extensive experience in various fields of science including biotechnology, phytochemistry, and human medicine.

Our R&D’s core strategy is built on utilizing cutting-edge bioinformatics tools and integrated approach for drug discovery, core expertise in disease areas (auto-immune diseases that lead to inflammation, fungal and bacterial infections) and insights into ancient medicine. Our R&D is enabled and driven by four main strategies, namely, collaboration and patenting, technological expertise, focused disease area, and diverse scientific talent pool.

Principal focus

Our R&D focuses on discovering new therapeutic molecules and enhancing the therapeutic capabilities of the existing ones. The key focus area of our research is skin inflammation. Our R&D function is actively involved in widespread research of phytochemicals and developing new therapeutic molecules for treating auto-immune skin diseases such as psoriasis and skin infections like acne, bacterial and fungal infections. Deploying cutting-edge instruments of bioinformatics for discovering new candidate drugs for treating skin ailments is one of the many pioneering initiatives of Atrimed.

Based on our insights in ancient medicine, human diseases, biotechnology and plant chemistry, we provide corroborative evidence to old medicine through novel methods. Atrimed collaborates with renowned medical research centres and hospitals and conducts clinical trials and lab tests to translate old drugs into new treatments.

Achievements

Atrimed has been selected as one of the top 100 technology-based start-ups across the state of Karnataka by Elevate 100, an initiative of the Department of Information and Technology, Government of Karnataka.

Key innovations

  • Reached potential breakthroughs in developing remedies for treating psoriasis and acne. Atrimed has offered more than 70 unique formulations in the market.
  • Established a bioinformatics lab to conduct molecular docking and study the interactions between ligand-protein and protein-protein using highly advanced software.
  • Constructed a natural product library that could serve as an unsurpassed source of new pharmaceuticals. The library holds 10,000 natural product extracts, which includes all the molecular structures that have been reported so far, and a virtual library which contains their secondary metabolites.

Organizational capabilities

  • Microbiology
  • Clinical development
  • Fermentation development
  • Bio-separation and bio-physical characterization
  • Process development
  • Non-clinical development
  • Biochemical, immunological and tissue culture techniques

Facilities available at Atrimed

Proteomics Lab and Small Molecule Analysis Lab

  • The laboratory was established to meet the necessity to establish proteomics-based research. The goal of this facility is to support the studies and projects that need proteomics technology. This facility enables the expression and characterization of proteins (produced or modified by an organism).
  • Available instruments:
    • 2D-gel systems and Nano differential scanning calorimeter for protein analysis
    • LC-MS
    • HPLC chromatography systems
    • AKTA prime
    • Microplate reader
    • Microplate washer
    • Multiplex immune assay system

Microbiology Lab

  • The microbiology laboratory was established to provide disease identification methods and suggest treatment methods, by facilitating the growth, control and administration of microbial cultures that are subjected to further testing.
  • Available instruments:
    • Laminar Air Flow (LAF) units
    • Spectrophotometers
    • Incubators
    • Shakers
    • Micropulser
    • Freeze dryer
    • Anaerobic chamber (bugbox)

Confocal Facility

  • The confocal facility was established for image acquisition in various areas of bio-medical research. This facility is involved in microbial and animal cell culture applications.
  • Available instrument:
    • Laser scanning confocal microscope with spectral facility

Gas Chromatography 

  • The gas chromatography instrument allows for the characterization and purification of potential lead molecules.
  • Available instruments:
    • Cold room housing the chromatography system
    • Gas purification panel

Flow Cytometry 

  • The flow cytometry technique, which allows for the detection and measurement of physical and chemical properties of a population of cells, was used to enable cell counting and sorting of primary and human cell lines.
  • Available instruments:
    • Flow cytometer
    • Cell sorter
    • Cell counter
    • Cell analyzer

Fermentation Room

  • The fermentation room houses several fermentors that are used in the growth of bacteria and production of metabolites.
  • Available instruments:
    • Small-scale fermentors
    • Large-scale fermentors
    • Homogenizer

Histology Lab

  • Histological samples of various tissues are prepared in the histology lab for examination under a microscope.
  • Available instruments:
    • Binocular microscope
    • Cryostats
    • Tissue processors

Plant Tissue Culture Facility

  • Plant tissue culture facility involves the experimental methods for maintaining, growing and manipulating plants and plant cultures under sterile and controlled conditions.
  • Available instruments:
    • LAF
    • Plant growth chamber
    • Fluorescence microscopy
    • Incubators

Molecular Biology Lab

  • The molecular biology laboratory offers an opportunity for DNA and protein isolation and analysis. It enables all aspects of recombinant DNA technology.
  • Available instruments:
    • High-speed centrifuges, table-top centrifuges, and ultracentrifuges
    • Gel documentation systems
    • Real-time PCR systems
    • UV-Vis spectrophotometers
    • Sonicators
    • Automated electrophoresis systems

Bioseparations Facility

  • The bioseparations facility is utilized for the separation, purification and recovery of a desired bio-product.
  • Available instruments:
    • Floor and bench-top ultracentrifuges
    • Floor high-speed and freeze drier

Bio-Safety Level (BSL) 2

  • The bio-safety level facility is designed for growth and manipulation of micro-organisms that are classified under BSL-2 containment criteria. Some of these organisms include Methicillin-resistant Staphylococcus aureus (MRSA), Candida albicans, Streptococcus sps, BCG, and Klebsiella.
  • Available instruments:
    • Bio-safety cabinets with adequate illumination and airflows